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In enzymology, ''phosphoribosylamine-glycine ligase'', also known as glycinamide ribonucleotide synthetase (GARS), () is an enzyme that catalyzes the chemical reaction :ATP + 5-phospho-D-ribosylamine + glycine ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide which is the second step in purine biosynthesis. The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide. This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). The purD genes often contain PurD RNA motif in their 5' UTR. In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5/7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS). In higher eukaryotes,including humans,〔 GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART),〔 forming GARS-AIRS-GART. == Nomenclature == The systematic name of this enzyme class is 5-phospho-D-ribosylamine:glycine ligase (ADP-forming). Other names in common use include: * phosphoribosylglycinamide synthetase, * glycinamide ribonucleotide synthetase, * phosphoribosylglycineamide synthetase, * glycineamide ribonucleotide synthetase, * 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase, * 5'-phosphoribosylglycinamide synthetase, and * GAR synthetase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phosphoribosylamine—glycine ligase」の詳細全文を読む スポンサード リンク
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